APPENDIX D
Experimental Data on Radioactive Strontium Toxicity
Refer- |
ence
37...
|
.
Anituat
|
‘
|
Human. oo...
NO. OF
.
animals
Goo,
Tsotope
pre,
wefem admin-
istered
Estimated
rad/dayin
Bislogical effects
Comments
skeleton
.02-0.4
3-60
All died soon after treatment, presutuably from disease for which
treated (breast cancer, polycythemia vera, osteogenic and other
sarcomas),
Iffects of radiation
|
indistinguishablte from disease.
|
|
Hluman..... | Joos,
Sree,
Human.....
Poo...
Sree...
38...
Dogs.......
24.0.0...
Srplus small
39, 40.
Dogs (adult).|
9.0.2.2...
Srplus small
Sr
¢ontamination.
10
0.06
16
0.1-3.1
16-500
0.25-1.0
40-160
Sr®
contamination.
Mycosis fungicides diagnosed.
Effects Indistinguishable from symptoms of disease. Survives without
follow-up.
Fibromyxosarcoma diagnosed.
[ffects indistinguishable from symptoms of disease. Survives apparently without ill effects.
30 day LD50 about I,c/gm_ retained. Biological response was
acute radiation syndrome.
4 died within 135 days, all suffered
early hemorrhages, survivors had
numerous bone fractures. 1 with
maximuin dose died at 8 yrs. with
skeletal changes, no tumor. 1 with
0.5,c/gm has bone tumor at
Dogs (adult) |
16
Sr*? plus smail
Sr®
contamination,
Srplus small
Sr
con-
Dogs (pup-
2 or more.
Dogs (adult).)
1........
Liv...
tamination.
es)
No
a
Bre le.
0,5
etsy
TTR eB
80
70
50
6e
py).
on ATHOUY KOd
4........
Tee
Patients treated at U. of Calif.
hospital in early ’40’s. In many
of the eases, the dose was admin-
istered in several subdivisions
over a period of a few months.
Other patients treated on which
data at present unavailable. Surviving patients should be followed, although with little expectation of significant findings.
Dogs included adults, young adults,
pups. Somewhat better correlation of effect with injected dose
than with retained dose.
Some survive at 814 yrs.
8
yrs.
1 suffered bone fracture at 3 yrs.,
slight localized changes in mandibles.
Fractures, loss of teeth, underdevelopment of mandibles. Tumer in
Some survive at 844 yrs.
Alive at 8 yrs.
1 dog.
Died 18 days. ..............0-2005
Acute radiation syndrome, survived
more than 3 months.
1 suffered fracture, 2 no lesions at
6 years.
Retention not measured.
Retention not measured.
FO INETTIRESPR a
Seat TE Ra etrT roeerpwen
7
.
‘“
re
.