tData from Romey et al., 1975. CPM “*'am based on FIDLER Surveys by REECo personnel. *<25,000 , 26 VEGETATIONtT #%>25,000 CPM 241am based on FIDLER Surveys by REECo personnel. 23 SOILt 2.0 + 0.40 22 8.3 + 0.30 + 0.25 + 0.20 5.3 5.0 24 +0.39 6.2 + 0.30 21 0.216 + 0.083 21 7,21 + 1.18 29 0,013 + 0,005 38 Carcass 6.0 6.59 + 0.13 25 6.01114 1.869 27 34 38 GI Tract 9.20 + 1.58 6.66 * 1.31 26 17.136 + 5.732 27 6.27 + 0.64 6.23 + 0.31 28 0.893 * 0.240 0.472 + 0.182 37 Pelt /Skin 12.17 + 3.67 11 0.148 + 0.302 11 9 0,022 + 0.012 12 Carcass 10.84 + 3,12 7.82 + 1.93 9 9.891 + 4.217 6.67 + 0.26 10 8.911 + 2.948 li 8 1.159 + 0.530 12 8 1.316 + 0.499 11 Pelt /Skin 20 GI Tract 7,18 + 1.75 11 6.263 + 0.137 16 5.58 + 0.84 SE xX 6.75 + 0.34 7.417 + 0.67 16 Pu/ Am xX SE N SE X High ActivityStratum** 239py N 0.008 + 0.005 Carcass COMBINED VERTEBRATES 394 | INSECTLVORE-OMNIVORE Whereas these results are prelim inary, and based on small sampl e sizes, levels of Pu in carcasses of some rodent speci es in Area 11, NTS, appear to be related to depressed leukocyte counts on a stat istical basis. There is no evidence at this time that these depression s are of a deleterious natur e. Additional data from examination of animals with high Pu body burdens are needed, We plan to evaluate blood cell formation in the bone marrow of these animals. By comparing blood cell counts in bone marro w with peripheral blood cell counts, one can Pelt GI Tract ) with Pu carcass burdens in P. longimembris, GRANIVORE In Figure 1, total leukocyte counts were Plotted against Pu carcas s burdens of D, merrtami and a least square s fit for the power curve Plotte d. Total leukocyte counts were negatively correl ated (P<.01) to Pu carcase burden s. In Figure 2, in a similar manner, relative lymphocytes were negat ively correlated (P<,01 SE Ta determine if Pu body burden s were related to blood cell reduct ions in rodents of Area ll, NTS, corre lation coefficients were determ ined for blood cell counts and Pu body burden s. Significant depressions in some leukocyte counts were correlated with eleva ted Pu carcass burdens. X and Carter, 1951) and 247cf and 252cf were suggested to be at least equal in toxicity to Pu in beagles (Dougherty, 1972). | Pu/ Am with 3.1 uc/kg or more, Sanderson and Jackson (1972) found a Similar lowering of white blood cells and lymphocytes in rate with a intraabdominal injection of 2.5-3.0 Ci Pu. Bone marrow aplasia was observ ed in Tats and hamsters dying withi n 30 daye after injections of 50 uCi/kg or more of Cm and Am. The hematologica l effects of 24.Am were simila r to Pu in growing rate (Langham 239py 67) and Durbin (1972, 1973). han normal hemaglobin value in moribund mice after injection of 15.6 ue/kg Or mote and a depression of peripheral leukocytes Low Activity Stratum* Laboratory studies on the effect s of Pu on the hemopotetic system s of mammals (Moor et al., 1976). HEMATOLOGICAL STUDIES (values in nCi/g ash) home ranges. Pu/Am ratios in the GI tract, howev er » Showed relatively low varia bility and soil and vegetation. This may imply that inhalation is the main route of Pu entry, as has been Sugge sted by most other investigations, or it may imply that Pu and/or Am is prefe rentially absorbed in the GI tract. The much higher variability in Pu/Am ratios in the pelt 1s consistent with the former hypothesis, 233py and Pu/Am Ratios in Granivores and Insectivore-Omnivores From Area 11-C, NTS 3. Pu uptake evidenced by tissu e burdens and concentration ratios may be Telated to the species of anima l considered. In Table 2, P. longimembri.a had significantly higher (P<.01 ) Pu tissue burdens and conce ntration ratios than D, micYops even though both are granivores. Data from animals of different trophic categories are presently being analyzed (Table 3), Pu/Am ratios are highly variab le in Pelts and carcasses o f small mammais and in some species are Significantly different Table 3. 2.