}
3
i
i
epg tefbuth aRina atehHeof thevth
rote
‘ay. basis'tg
atin
inePetranta Pt sities
ft
eid
e*petab.iitBohs Hidofthis feyie idle’ ¢ine Hrauldntoe”
limited$0 lubility wascompared with that’wine previg: ly“atuidte ‘ali.
_out simulagts; an ionic quid aerosol and:Aimud-liorryeero80l.” The
Pe wt
simulant was also administered by gavage‘to providedatapon¢the’ uptake
of fallout by ingestion a3.cpm aredwith inhalation,
DAV te
Follo
e dry-~panticle simulant)
ctr
peared primarily ‘i ithe GI tract,
a japr a
quic
A{Port
‘Lesser conce tratitny
skeletona ad thyte
reeniatlgey
5P
9°
0 found in thethead, liver,
“Thetradi
IEE
vity.we removedivery'rapidly!
alnyBonyia@ In ibaha
The ratia of a,sty,
H fpe GI x4ct to that in the respiratory aystjem
following exposure ¢Me onic,
dd-slursy and dry-particle simujants
was 3.2, 12 and 80,:Treepactively. The rate of bolageiliaatign of
the dry-particle simulant.material from the skeletoniand
liver wagicon- .
siderably ‘greater than was noted with the previously*tafed tonic:‘pimi
lant, Interms of total respiratory and GItract activjty’gt1 hr, ‘the
‘
skeletal sfue wastwice as high for the ionic simulantiasfor‘oT
particle sjmulant, While the reverse was true for theliver!activit
Following the administration of the simulant by gavagey:‘the initipt
distribution of activity in the GItract and in the tissues: was very similar
SES
to that following inbalation exposure, It was found that the! absorption
across theGI tract provided an important portal of entrysfor the:-dyyparticle simulant into the systemic circulation following’an inhalatjon
exposure,’ The composition of the simulant materialin:thevarioug
tissues during the first 4 days following exposure appeara‘to be deminated by,one or a group of fission products, as seen from the similarity
of the radioactive decay rates for most of the tissues, ‘The resulte wer
similar fer both inhalation exposure and administration by gavage: Ex»
ceptions tp these findings were the thyroid and skeletal tissues,
for
having an‘affinity for the short-lived iodine isotopes, and:the latte for
the longes-lived fission products.
The thyroid received the highest dose to any tissue from the inteynall
deposited fission products,
The GI tract received the next highe at: dose,
which was, however, less than 10 per cent of the doge to.‘the thyroid. .
The dose to the skeleton, while lowest in the 15-day ‘periodstudied, will’
~ ye ann ate gm phen’ ge
wee
probably be greater than that to other tissues over a: tongs? period:‘of .