ore se ee ee
Th1e expe imental appad Bfus for generating the aerosol and exposing
the animala'(scc Fig. 1) Was previously described.4® The equipment:
congisted of: (1) an aerogh]generator, (2) the animal exposure cham.
gl
a
2
A generator was design ‘to provide a stream of airborne dry parti
cles. at a cqnstant concent tion level (3,2 * 1078 pc/ml).® The rotation
of'the outey'tube provide R constant advance of @ brush against theisurBticles. The particles thus agitated werepicked
a.
jvered to the exposure chamber at a flqwrate
.
i.
ye
i
ithe prpsent study, Menice were exposedto the dry-particle-fallou!
simblant ae manner ide¥ Bical to that used with theionic simulant,4 ‘In
ist
Faolution can
Bing a measured amount of the Sryieimajeet
h tube to 36micgy..
dminiter ed by atg ;
e animals were SAG; : ced in groups of‘bleach, starting at
3 | hy
hrlafte
ure and at various:iitervals upto'l5 days, ‘ The experimentalpyOre fostmensuring! hamictivity of the:fisgjonproducts in the ee
een described in‘a Bavious report,
“ye
¥
he distribution of:i" ae activity was determined in the following
oxgans and'tinsues: regulatory tract (starting at the upper end ofthe
cornaeote ath aa
ber,(3) sample collectorHor collecting particles (for determination.of
wee
aerosol concenty tion) and (4) supporting equipment (pump,etc. ).
a
4
a
a
a
hehe
lazynx) and’‘lungs, liverg ibia, thyroid,head,and GJ tract and contents
(fram top’Of esophagus:
ith:
al region), The. autopsies were carried out
care to avoid crag
p tamination,
cs
he ‘taspe assays wer@—perforined by determining the gamma activity
‘sodium iodide gang ma scintillation counter. The tissues were
ted ig Coors porcelg@ crucibles and positioned under the crystal.
ity was not meg gured due to the inherent difficulties with pre»gamples for cqinting. However, previous experiments’have
he gamma ac Ayity measurementsipatisfactorily reflectt the
-product acti sity.
#
RESULTS AND “——
Initial Uptake ofthe Iph
a
:
The distribution of the
v.
*
a
“a
.
3
ay
4
the airborne simulant for 3 hr, and serially
a
x
4
adioactive fallout simulant in the tissues and
e
A
‘
:
ervsolAnimalTisue
organs of mice exposed
x
u
4