At 25 r 25% of individuals were above the normal range; the
rest were scattered through the normal range and resembled controls in their
distribution.
At 50 r 33% were above the normal range, and the distribution
of the remainder showed a shift to higher values.
At 300 r 65% were above the
normal range and the shift was still more obvious.
At 525 r (only 14 mice) the
shift appears to be yet more marked,
Interpretation of the meaning of this finding cannot be under~
taken without a great deal more investigation.
On the basis of clinical work
with human patients increased cholinesterase values are associated with hyperactivity of the bone marrow and the presence in the peripheral blood of an
increased number of young cells, not necessarily accompanied by a reticulocytosis.
f/-
f,
Clinical Studies of Red Cell Cholinesterase,(J, Sabine, H. Miller
1)
Acute Leukemia:
A child has been followed for four months.
October the disease was fully developed.
cholinesterase values were low-normal.
In September and
Transfusions were required.
The
In November a spontaneous hematological
remission began and the patient's condition has improved markedly,
The cholin-
esterase values began to rise before the presence of remission was otherwise
established.
During the past month the values have been at the upper limit of
normal, and the hematocrit is maintained at around 40%.
not impressive (1 to 34),
Reticulocyte counts are
Although the total number of reticulocytes produced
during the past six weeks has undoubtedly been large, the response at any given
time is not sufficient to give a reticulocytosis.
It has been proved previously
that the high concentration of cholinesterase in young cells persists long after
the reticulum has disappeared.
The finding in this case,6thers
Classification changed
to
a72¢,
Supports
the view that the cholinesterase MESy eed ptire
tes the
:
reticulocyte count.
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