35
TSHconcentrations were normal. For this reason,
TBG-binding capacities were determined in a
numberof subjects with abnormal Ty, values.
TBG analvses were done on sera from 536 subjects (25 Rongelap and 31 Utirik) selected as representative of three groups: people with low, normal, or high plasma T4 concentrations. Two
methods were used: TBG was measured byradioimmunoassay (M.C. Gershengorn and J. Robbins,
unpublished observations, 1974) and TBG-binding capacity by reverse-flow paper electrophoresis.
The results were comparable since the meanratio
of TBG-binding capacity (ug T,/dl) to TBG
(mg/dl) was 13.9. On the basis of one mole T,
Table 31
Total and Free Thyroxine, Thyroxine- Binding Globulin, and Thyrotropin Levels in Marshallese
TBG, pg/dl
Ty, pedi
Subjects with TBG-bind capacity <14 pe T,/dl
827
7.6 (1.06)*
5.1
917
981
2115
2126
2144
2174
1.72
1.55
1.43
-
77
9.1
7.0
4.4
4.9
4.0
3.21
3.20
3.76
t4t
1.57
1.50
< 1.0
<5.0
-
48
3.23
1.55
<1.0
1.29
<2.5
-
Mean
S.D.
9.02
*+2.39
4.1
850
14.0(1.04)
2137
19.9 (1.37)
2212
20.1
2232
16.2 (1.54)
2168
14.4
2230
2206
2182
2218
2221
17.7
14.4
14.3
13.6
2257
17.3
2136
*
°
0.998
1.12
4.34
3.33
1.44
4.6
S.D.
O1f
3.08
9.2
2.90
7.4
5.0
3.0
4.8
2.77
2.92
3.04
2.68
8.8
2.94
° 5.0
48
Mean
S.D.
2.94
1.84
2.42
1.42
1.79
2.67
16.65
5.9
2.60
1.53
+2.58
+1.87
+0.503
0.597
2.6
L.14
1.66
2.8
<2.5
3.6
<5.0
2.0
<2.5
2.1
4.9
2.01
1.53
1.81
0.903
2.4
10.8
13.6
0.872
1.19
-
11.03
1.42
1.43
+0.468
+0.358
56.1 (4.56)
12.9
32.8
31.8
7.0
18.2
*TBG by RIA, mg/ml.
2.1
6.0
2.57
0.885
+9.62
2.6
1.16
2.05
1.46
0.912
1.29
1.45
43.5
4.2
3.6
<2.5
6.1
2.15
<2.5
0.92
21.9 (1.28)
7.7
3.1
2.3
+ 0.230
2.72
47.6 (3.92)
2217
2256
+0.40
46
6.1
Subjects with TBG-binding capacity >26 ug T4/dl
2138
37.0 (1.52)
9.0
2229
33.7
5.9
891
2.80
4.2
15.3 (1.06)
‘Mean
1.73
3.12
2.94
*+0.543
15.5
4.23
3.2
3.8
Subjects with TBG-binding capacity 14 to 26 ug Ts/dl
2135
3.37
3.53
3.24
13.7
11.9 (0.94)
2183
TSH, pU/ml
4.4
4.4
11.1 (1.03)
220
2248
Free Ty, ng/d)
7.0 (1.20)
8.0 (0.69)
7.1
2193
DFT, x 10+
*+4.63
1.22
1.88
0.991
t.54
1.32
1.80
2.1
2.7
4.4
tee
CN a en
Subject No.