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for publication and supmitted (in manuscrist form) with a former annualf
report.
Since
it now appears that we can distinguish C-ceil neoplasms from other undiEferentiated
solid ceilular lesions in irradiated animals, several thousand microscdpic preparations
with radioautcgraphs
are being re-reviewed.
Thus, the previous
manscripts will
soon be modified to account for the two types of solid cellular tumorsfand resubmitted.
The Contribution of the Marshallese To The
Radiation Study In Our Laboratory
As has been mentioned above, the study of the Marshallese has c
deal to the study of radiation effects on the thyroid.
radioiodines in the thermonuclear fallout in 1954.
The Marshalle
They are continuing
in their thyroids more than 25 years after exposure.
to develop masses
The tissues are
The fresh tissile when removed in
this institution by us has been studied promptly by methods establis
in use under this contract.
were exposed to
We have now perjprmed thyroid-
ectomies on 45 out of a little over 330 that were known to be exposed}
of great importance to the study under this contract.
ibuted a great
and maintained
Autoradiographs for 131; have been prepafed on all tissues
removed.
This investigator has participated in nine of the annual survey Pxaminations of
thyroids of the exposed persons in the Islands.
Dering the course off the present contra
(since 1975) 18 exposed individuals have developed masses and have
brought back to
Brookhaven National Laboratory for clinical study and then to us for
[thyroid exploration
All exposed thyroids cperated since 1975 have contained adenomas and six have had carcinomzs.
To date we have removed 9 carcinomas and 2 adenomatous n
es with papillary
carcinoma fran the 45 exposed individuals of all ages fram several afolls.
the carcinanas had metastasized to regional cervical lymph nodes.
came from an atoll with extremely low exposure.
F
Since this is a
seems to develop thyroid nodules, the relationship to the radiation
radioiodine is most impressive.
Three of
carcinomas
ation which selda
ich was primarily