wR aE i ry . TS BD The ote <. Arye spin fare Va sabeot SioeVU ERE we ae! aad #8 SUIEETSY ote Pere aS PRIVACYACT MATERIAL REMOVED:2 =o= _ STUDHS,OF,XOTAL,,PO vars snr. Thats“4 dee . wn ov pyr es ‘The pos : 70 | F | s20 19.4 pees Al7 y,water of‘the fouryoung Bie S . tS ab} eeeeay wa s,60.4%of ewig gabe itiu aterLat TALE,‘dehassembs : “Tealboy wetefsaiwipovigh “h S ‘between , Mis!between af Beh ng tne 34and: ad fohave if ¥s ; mand Sokaant e i- au detand. att. wk yaa. A3jnt eafl ne gtpup u Ot feeeejet ota bleay ee ayerag- hey tall EH Chaerved t ially or ght,‘tan ing. 2 Fes bodyweig - ear twenties. g and Ste rs late sAGensa (133.)F486°[215-1 47.21": - iea an; er ng sat Tage a he eae tndoubt 6: FU $3.2°7 2n.8.f 339.71:oe ae -“ence edlygrea tlysue ncedt by‘the: dif. Ngodte (etd ty peate Ethe § aad di : Mean vn F. . 48.5} - | : a nS - Ss . Lae RY oS . ayshee |B, With an 2 36° F 719 60 M] 52. ok’ sa: 65° F si || 49.6 26.6] $3.2] Ascites, _ ~ 47 ol ; + a ae . te ].71-3 vt ' 40.2| anasarca - 56.4) Ascites and fio. +4 edema? Sa} M}-59.5. 31.5 [1$3.0] Ancites: Mean ot J 60,;| M S&L, 30.4 |, 52.3] Ascites 53,3 63:3] '36.8'] S60)" ae iow, : soph! & 43). studies. because they would, producevery low radiation dose ;. yet the’ specific activity’of plasrha (bodywater)’gavea‘countingrate‘thatwasjgreater thanbackground by’afactor'of20tg30." Dosage rate and total dose werecalculated for a 70 kilogrammanusing anaverage betaparticle .aseeeaes ectedin entage ol. a teSoo an ei Nae ok fedaeive ws “aE - yet, mt hee iidOFF data‘toatablih a,reliable Helene,andage., Tt:is,felt that'such’s cortelation would, inany event,be.¢s- sentially& correlationbetween fatand age. ‘Since’ individuals:differ, markedly in degree of obesity,the: proportion of body water normally pres- entwill?‘Wary/accordingty andthus’may ‘imask any positiveindicationof altered waterbalance.)Body .waterdeterminationsindisease states consequently appear tobeoflittle -value as a quantitative measure of-water-retentionor deficiency unlesstotal fat calibe determinedindependently. AsSteele, Berger,Dumhing,and: Brodie (17) have alrealy:stated, an‘obese‘person.can develop edema. and still haye a smaller: proportion of body water than‘a- lean, ‘nota individual,. .. This. explains the lack of a significant,difference . in the proportion of body water observed.in cardiac patients with and without: edema, shown in Table IV.. pols _The‘average percentage of total bod), water. of Group. A,.(Table V), ‘whichtonsists whollyof feance of tritiumwith'ahalf life of 10 days.""* The, maximum! dosage rate,|whichwouldoccur males, was 43.5%.as. compared to44.6%.for, norat the time, ‘ofinjection, is;“dosage. rate=(2) mal] females (17), In Group B there arefive male (37 x 10"): (6,000) (1.64:x10)/(70):= 0.01 patients.‘with an. average. body. water. of. 55.2%, rep./day where 37° 10"is the’numberofdisin- which js, only, slightly .higher.than our ;figure tegrationspermillicurie’ssec.,-and1.6410is a (S2.1%)‘for svSrmal males. The two femalesiin factor forconversion.from‘electron‘Voltsper sec- this: group had total body waters considerably ond to roentgenequivalentBhysical(rep) Per.coy. above the averagefornormal females. ' Little emphasis was placed: om:the :measurement assuming 84ergsiper.rep. * of body water.turnover in. this investigation because Total dosewas calculated bythe formula: of previous:work on‘this aspéctofthe'problem by energy of 6 kilovolts and an éxponential disa Total dose==dosage rate>halftime/In2=z,(0.01) Pinson, and Anderson (12). Thesé'linvestigators, Lo - 0)/(0.653). =0.14 rep, using fridia,found. biological ‘half-lives’‘of body which represents the integraitinofthedéesze rate waterineight normal subjects onan ad libitum from the time of injection to infinity. ‘The radia- water intake to range from nine to 14 days. These tion dose during the first week is considerably less | values agree closely with those found by Schloerb, than the generally accepted tolerance level of 0.3 ‘and his associates. (11) using deuterium. When the water intake of one of these individuals was roentgen per week. . tet % 9043061 a. F PRIVACY ACT MATERIAL REMOVED