POC eMENT SURES Unversity of California at Berkeley y CA The Bancrott Library/The University Archives. Berkele RECORDS SEPIES TITLE Gergen Kenneth Papers Scott BANCROFTIUARC ID NO. SO 81 COPY CARTON NO. OER NAME “enaat (952-1963 NOTES pa f 13 papworn lta WENNESLAND. BROWN. HOPPER. HODGES, GUTTENTAG, SCOTT, TUCKER. BRADLEY the data only slightly, aiter effects of height and weight had been accounted for. found in two investigations particularly devoted Vrbe is primarily dependent_on total muscle mass and, equally well, the thesis that bloodvolume may be more dependent on lean than on total body mass. In contrast. Bass. Buskirk, lampietro and Mager (22) found no increase in Vpl or Vrbe after three weeks of vigorous physical-tonditioning and Buskirk (23) was unable to demonstrate differences in Vpl or Vwb per unit of total or fat-free body weight in moderately or rigorously trained athletes and nonathletes. The demon- stration by Kjellberg, Rudhe and Sjostrand (21} of large differences between the blood volumes of — athletically trained and untrained persons requires re-examination. The carbon monoxide method which they used is particularly unsuitable for this problem, since 15 per cent of the test dose of gas leaves the blood during the measurement and goes mostly to muscle pigments (25. 27). SUMMARY 1. A group of 201 men were screened for health and classified as to age, habits of physical activity and somatotype. The red cell volumes (Vrbe) of these subjects were measured with Cr** tagged cells; plasma (Vpl) and whole blood volumes were derived indirectly from venous hematocrits. 2. Regression equations were derived, ¢xpress- ing the relations of the volumes to body weight and height and to combinations of these measures. From these data a chart was devised from which the expected Vrbe and Vpl for a man of given height and weight can be found conveniently. 3. In the sample of population examined. age, elements of the somatotype and habits of physical activity were found to influence the variance of Urey aa Ae REFERENCES Rowntree, L. G., and Brown, G. E. = The Volume of the Blood and Plasma in Health and Disease Philadelphia, W. B. Saunders Coz 1929, p. 54. 2. Gibson, J. G., 2nd, and Evans, W. A. Jr. Clinical studies af the blood volume. IT. The relation of plasma and total blood volume to venous pressure, blood velocity rate. physical reeasurements, age and s¢x in ninety normal humans. 4. clin, Invest. — 1937, 16, 317. 3. Gregersen, M. 1, and Nickerson. 3 L -Relation of blood volume and cardiac outgut .to body DRe. J. appl. Physiol. 1950, 3,329. . = 4 von Porat. B. Blood volume deermunations with: the Evans blue dye method. Acta raed" scand, 1G},: » 140, Suppl. 256, 1. . §. Allen, T. H., Peng. M. T., Chen. ER. BoingT2F; Chang. C., and Fang, H. 5. Predictionof bic volume and adiposity in man from body weight and cube of height. Metabolism 1956, §. 328. “6Sjdstrand, T. The total quanuty of hemoglobin in man and its relation to age, sex, bodyweight and height. Acta physiol. seand 1949, 18, 324, 7. Berlin, NW. I, Hyde, G. M.. Parsons, R. J., and Lawrence, J. H. The blood volume in various medical and surgical conditions New Engl. J. ed . 1952, 247, 675. 8. Hedlund, S. Studies on erythropoiesis and total red cell volumecongestive heart failure. Acta med. seand. 19537146, Suppl. 284. 1. 9. Reilly, W. ATrench, R. M.. Law F. Y¥., Score, K. G., and White, W. E. Whole blood volume determined by radiochronmmum-tagged red cells. Comparative studies’ normai_and congestive heart failure pa- tients. Circulation 1954. 9, 571, 10. Eisenberg, 5. The effect of congestive heart failure on blood volume as ‘determined by radjochromium- tagged red cells. Circyjation 1954, 10, 902. 1]. Schrerber, S. S., Bauman-A., Yalow, R. 5., and Berson, S. A. Blood volume alterations in congestive heart failure. J. clin. Invest 1954, 33. $78. 12. Gunton, R. W., and Paul, W. Blood volume in congestive heart failure. J. clin. Invest. 1985, 34, 879. 13. Samet. P.. Fritts, H. W.. Jr., Fishman, A. P., and Cournand. A. The blood rolume in heart disease. Medicine 1957, 36, 211. 14. Hicks, D. A., Hope, A., Turnbull, A. L, and Verel. D. The estimation and prediction of normal blood volume. Clin. Sei. 1956, 15, 557. ee increasing gtades of habitual physical activity. This supports Sjdstrand’s hypothesis (39) that SSHOMNta Garay have tins; (endomorphy) «4dr (ectomorphy} and obesity negative erfects Gn the residuals about the height x weight regression planes. Also. a slight progressive positivity of residuals was found with _ We have found that muscularity (mesamerphy) has a slight positive effect. while both linearity ACKNOWLEDGMENT The subjects were studied through the courtesy of Dr. M. DO. Wilcutts. Chief Medical Officer of the Medi-: cal Service of Neurmiler Hospital, San Quentim Prison,. State of California Department of Correetion. oy to theproblem of aging (18, 19), ly, Cadi studies (2, 20) and our own involved few subjects over 50 and since discordant results were s an i study, inasmuch as both the above-mentioned Cistiy of Cabt on 1076 [0 f/2 LEY