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Kénne th
Gardan
Scott
Happs
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FO / BI
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2. 2473
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RED CELL AND BLOOD VOLUME [IN HEALTHY MEN: Cr
tered. or c) methodologic factors. Influence of
the latter seems unlikely since the within-month
eect was as great at the end of the study as at
the beginning am~. since the personnel. procedures
and methods were
unchanged throughout.
E) Blood donations.
Fiity-three blood donors
were included in the series. Their residuals of
Vrbe and Vopl are plotted in Figure 3 according
to the interval of time between donation and ex-
periment. The points are distributed evenly
around the zero line which represents the pre-
dicted Vrbe or Vpl of each individualcalculated
irom his height and weight. Most of the residuals
were within plus or minus one standard deviation
Ineasurements enable us to estimate the amount
of variation due to measurement errors and short-
tern: temporal changes, The estimated standard
deviation of such variation was 64 ml. for Vrbc
and 211 mi. for Vwb. The standard deviations
about the regression planes described by Equations 3 and 11, Table II, are reduced only modestly
by taking into account the degree of variance
shown by the repeat measurements, which includes the errors of measurement and the changes
in blood volume of individual subjects from time
to time? Thus. for Vrbe almost all of the predic-
tive error seems to relate to intrinsic differences
berween subjects rather than to errors of meas-
urement or temporal changes within subjects.
of the mean predicted volume so that the vanatten
is no greater in this group than in the population as_. For Vwb this is so to a lesser degree; this volume
awhole.
The residuals showed no tendency tq in-
crease or decrease progressively with time, between 42 and 180 davs. For all donors, the mean
is either less stable or less accurately measured.
or both.
DICUSSION
residuals (ml.}) were as follows: Vrbce = + 17
1S.E. 27), Vpi= — 17 (S.E. 33), Vwb = + 02
13.E. 50).
Only the observed venous hematocrit values
were used in our calculations. It is recognized
2. Repeat determinations
culated-trom- the Cr°! space and observed heinatocrit becauseof plasma trapping in the hematocrit
eae
that the true \rbe is slightly smaller than that cal-
In 15 men the blood volume was re-estimated
one or more times after intervals of three to 31
weeks. The mean of the 20 differences for Vrbc
was 73 mi. (range, 10 to 160 ml.) and for Vwb,
222 ml. (range, 10 to 710 ml.).
These repeat
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