. FFICIAL USE ONLY -2The 115th meeting of the Advisory Committee for Biology and Medicine was held at Oak Ridge, Tennessee, on November 10-12, 1966. The meeting on November 10 took place at the UT-AEC Agricultural Research Laboratory, and on November 11 at the Medical Division of the Oak Ridge Institute of Nuclear Studies, Oak Ridge Associated Universities. ACBM members in attendance were Drs. Earl L. Green (Chairman), Philip P. Cohen (Vice-Chairman), Wm. F. Bale, Lemuel C. McGee, Robert D. Moseley, Morell B. Russell, Harvey M. Patt, (Scientific Secretary) and Miss Rosemary Elmo (Executive Secretary). Because of a prior commitment, Dr. Green was present only on November 10 and Dr. Cohen served as Chairman. Dr. Charles L. Dunham, Director, Division of Biology and Medicine, and various members of his staff, were also present. The ACBM was joined by Commissioner Nabrit at its executive session on November 12. The formal presentation by staff members at each of the meeting sites was followed by a program recapitulation with the Director and his senior staff. This provided the ACBM with an opportunity to examine in some depth various facets of the on-going programs and to ascertain program requirements and future developments. The ACBM noted that the UT-AEC Laboratory provided a rather unique opportunity for long-range studies with large animals. There is some question, however, about the desirability of continuing to maintain all of the animals now on hand, many of which had received poorly-defined radiation exposures in the field. The Committee suggested that a careful review should be made of the present experimental animals and that a critical prospective study of long-term effects should be designed. It expressed the opinion that some aspects of the program, e.g. radiobotany, could be phased out, particularly as staff members leave. The general lack of sophistication in plant work and instrumentation was noted. The ACBM was pleased to learn of the appointment of Dr. Thomas Noonan, which should strengthen the program with large animals. The desirability of interaction with the Medical Division at ORINS, ORAU, and the Biology Division at ORNL was emphasized. The ACBM proposed that a local advisory committee consisting of representatives of the three laboratories could provide a mechanism for fruitful collaboration in regard to the planning and conduct of future programs at the UT-AEC Laboratory. The organization of a committee along these lines will be initiated by DBM. In its discussion of the ORINS (ORAU) Medical Division program, the ACBM expressed the view that the local advisory committee proposed for the UT program could also be quite effective here. The low and medium dose rate facility in the Medical Division is a unique resource and it is hoped that much of the future program will revolve around it. There was some discussion of the probably diminishing importance of whole body irradiation for diseases such as leukemia, and of the desirability of applying instrumentation developed at the Oak Ridge National Laboratory to medical problems at ORINS, ORAU. The ACBM emphasized the importance of constituting a national committee for review of the clinical research protocols. This is due locally at present and a somewhat broader point of view would appear to be desirable. OFFICIAL USE ONLY