Stafford Leak Warren Warren did his residency at Huntington Hospital in Boston; he had an appointmentat the University of Rochester, where he did pioneer research at the Medical School on X-rays and cancer. His connection with Rochester is very early. During the war years, it was noted that the Rochester lab was the only one that could do animal work(p. 495, v. 2). Stone's group wasat the time working on fluorine, an offshoot of Dr. Harry Hedge's work at Rochester on fluorine in teeth. Stone and Warren knew each other quite early on. Warren seems to have been responsible for worker safety at the differentsites, especially with respect to the handling of radioactive substances, such as uranium. The Manhattan District's policy, according to him, was not to undertake contracts with firms which did not have adequate worker safety--for legal purposes. (This was however waved in the case of a Canadian firm, where the Manhattan District agreed to take unprocessed uranium). Warren's recollection of Hamilton (p. 580, v. 2): "I didn’t have much problem with the Berkeley people because Dr. John Lawrence, Ernest's brother, and Dr. Joseph Hamilton had already laid down the safety criteria for the cyclotron operation. John had gotten interested in some navy work so he didn't participate muchin this [[use ofuranium ys thorium*]} but we relied on Dr. Joseph Hamilton. Dr. Hamilton had easy accessto all the new fission products from the cyclotron group right there and then doing whatwecall quick anddirty experiments. First ofall, they determined whether it was highly toxic material, whether it was a bone seeker that destroyed the bone marrow,how rapidly was it excreted, and so on. He was a beautiful experimenter, he did all of his on three points per dose level, which meantthree rats. It was very cheap and very quick. And he could sacrifice his animals at intervals of days or weeks. He would cometo a meeting every month and give day-to-day reports. We considered him a kind of explorer. He didn't ‘ want to do any of these long-term, big-scaled things. He was not that kind of an operator. Hehad a mind that was very quick and imaginative and he could take these small amounts from the cyclotron and in a very short time [finish the experiment].” (* italics are my additional notes for comprehension) Lawrence Berkeley Laboratory Archives and Records Office Human Radiation Experiments Search and Retrieval Project Anna Berge Research Notes Electronic DocumentTitle: Bancroft/misc Apmil 1, 1994 3

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