MEDIAN WEIGHTS '1958-1963 ; ot I po . : Boys ——« =xPOSED 2 —-o CONTROL f Je WEIGHT (POUNDS) 120 lOO te "4 1 ! sol — lOO . 4 4 = ' at a I a, 4 1 ga | oa a Or aa 20h — 5 \ 4 | 6 8 10 AGE (YEARS) : i2 4 w~———= EXPOSED (20 a = 0 CONTROL 4 io MEDIAN WEIGHTS '998-1963 ! : 1 i 1 i rT GIRLS 4 \ 80- | I a ge “ : Summarizing Discussion. The two giris who had complete thvroidectomies developed signs of hypoparathyroidism which responded to treatment. _ ty" A 60 _ 4 _ “a aan “or i we - - 20k — ot 4 L L 8 , thought to be malignant. Sections of the tissues were reviewed by a numberof pathologists, * all of whom agreed that the nodules were not malignant and resembled in many respects adenomatoid goiters seen with iodine deficiency, with its characteristic regenerative rather than neoplastic proliferation. However, in the Marshall Islands, where fish and sea food are mainstaysof the diet, iodine deficiency ts not likely and goiters are rare. Figure 10 showsa picture of the gross appearance of the nodules and Figure 11 shows a microphotograph of one of the glands. The likelihood of these nodules being radiation induced is discussed in the x - (4 . 80 — { Lt 3 L 1 10 i2 AGE (YEARS) . L 14 6 Figure 17. 16 Figure 16. Brn, 1 WEIGHT (POUNDS) 40 : were in bovs 12 and 17 years of age and one in an adult woman +41 years of age. The nodules appeared grossly similar to those described in the teen-age girls in this report, and these cases will receive study and treatment. Growth and Development Sivdies. Anaiysis of the statural data from the 1963 survey indicated the persistence of the trends previously reported. As shown in Figures 12 and 13, no difference was apparentin median statures between the exposed and control groups amonggirls and between girls born to exposed and girls born to nonexposed parents.* Among the boys, however, retardation in statural growth of the exposed group between the ages of 3 and 12 years as compared with that of the control group was again noted ( Figure 14). The difference in median statures between bovs "Sections oftissue were reviewed and reported on bv Drs. $. Warren, New England Deaconess Hospital: G.H. Klink, Armed born to exposed parents and those with nonexposed parents was also evident in 1963 (| Figure 13). This difference has been attributed to the fact that the boys in the group with exposed parents were, on the average, 4 months younger than the boys in the group with nonexposed parents. No statistically significant differences were noted in body weight curves between exposed and control children (Figures 16 and 17). In skeletal maturation, the trends reported in the previous studies 5. Lindsay, University of California Medical School. statistical analvses, Parathyroid function returned in No. 17, but No. 21 still requires therapy including thyroid extract. In the third case (No. 69} only a partial thyroidectomy was done, and she requires no therapv. Nore: During the |1th-year survey now in pro- gress (March 1965) 3 new cases of thyroid noduies in the exposed group have been detected. Two Forces Institute of Pathology; C. J. Stahl, U.S. Naval Hospital at Guam; H.A. Johnson. Brookhaven Nationai Laboratory, and *Or. K.M. Griffith of the M.D. Anderson Hospital did the