39
Bone Marrow Examinations
row examinations will be carried out in both these
The differential counts of bone marrow aspira-
tions on 6 individuals, + exposed and 2 unexposed,
are listed in Appendix 18. The differential counts
showed that in 3 of 4 exposed persons there was an
alteration in the myeloid-ervthroid ratio manifested by an increased numberofred cell precursors. In addition to hyperpiasia, abnormaiities of
chromatin material with doubie nuclei and increased numbersof mitotic figures were seen in
the normoblastic series (Figures 50 and 31). One
of the exposed (No. 63) and oneof the unexposed
(No. 948) showed increased lymphocytosis of 33%
and 27% respectively. This was reflected in the
peripheral biood counts in which the total number
of leukocytes was normal but the lymphocytes
were increased to 31% and 56%. Thesignificance of
this finding remains obscure, but repeat bone mar-
cases during the 1965 survey.
Red Cell Mass and Plasma Volume Studies
During the 1961 and 1962 surveys blood volume
studies were performed on a group of Marshallese
subjects and on a small numberof Caucasians
who had beenliving on the islands for one year or
longer. Sodium chromate labeled with Cr*' was
used to tag the erythrocytes. With body weightas
a criterion, it appeared that 15 of 23 subjects, both
Marshallese and Caucasian, showed a significant
reduction in red cell mass and/or plasma volume.
In order to establish the relationship of blood
volume to lean body mass tritiated water was
administered orally to each of 21 Marshallese
subjects during the 1963 survey. In addition, determinations were made ofred cell mass and blood
volume by using Cr*'-labeled sodium chromate.
Table 20
Total Blood and Red Cell Volume Data
(WT. =gross weight; TBW =total body water: FAT =fat as % gross weight;
LBM =lean body mass: RCV =red cell volume; BV =blood volume)
Subject
No.
822
832
836
838
841
873
381
882
885
895
916
928
932
938
042
959
960
1007
1043
1501
Jeon
Ay
WT.kg
54.34
46.36
56.36
66.13
66.81
61.36
68.63
54.77
61.81
35.90
63.63
37.27
46.30
40.00
57.72
60.00
38.63
71.36
41.81
66.81
«63.18
Av RCV(1)
TBW.!
38.1
25.0
35.3
417
31.9
43.2
32.8
39.9
41.0
29.0
32.6
29.4
26.2
22.0
276
32.2
24.8
412
26.4
43.3
39.8
33.5
_
TBW.%
68.8
53.0
617
62.2
47.0
69.4
7.1
71.8
65.3
31.3
30.4
30.5
35.7
54.1
471
52.8
63.1
56.9
62.3
64.0
61.9
AvBV() _
AvTBW1)7239) ASFBW oy 70-09
FAT,%
44
26.4
14.3
13.6
34.7
3.6
34.6
03
93
28.5
30.0
29.9
22.6
24.9
34.6
26.7
12.4
21.0
13.5
11.2
14.0
LBM,kg RCV,1 BV!
52.1
1402
3.260
34.1
0.849 2.388
48.3
1428
3.320
37.1
2108
4.053
43.6
1150
3.196
59.1
1670
3.631
43
1996
4.247
34.6
1.131
3.426
36.1
1.760
3.825
40.0
1.070
2.488
43
1.091
3.031
40.2
0.927
2.305
35.8
L274
2.963
30.1
0.886
2.331
378
©«0.860——2.150
44.0
115)
2.877
33.9
0.774
2.150
364
1.620 4.155
36.2
1.066 2.664
39.3
1.843
3.840
344
1.310
2.673
1.303
3.102
RCV/LBM,
ml/kg
26.9
24.9
29.6
36.9
26.4
28.3
44.7
20.7
314
26.8
24.5
23.1
35.6
29.4
22.8
26.2
22.8
28.7
29.4
31.1
24.1
28.3
BV, LBM,
ml kg
62.6
69.2
68.7
71.0
133
614
95.0
62.7
68.2
62.2
68.1
623
32.8
774
36.9
63.4
63.4
73.7
3.6
643
49.2
68.2