Subject:
Proposed at Operation Knothole or next nearest occasion.
Small test to establish suitability of a strain to replace
LAF.
1
for routine AB and related work.
ech cy sy
Suggest set-up at one or two stations, anywhere around tue Lg,
SO dose or
slightly below, mice of a pure strain for orientation eposur @ to find
out. whether this strain could replace the LAF, hybrids now in use.
R
The exposure is to be made by those interested in acute studies as
biological dosimetry; survivals can be taken care of by us.
The LAY, mice are excellent, but for purposes ef AB exposure
esl-stucies are Very ex-ensive and in my @inion are not necessary. In
ppemeeont
orde. to get LAF, mice, a lerge breeding colony ef two strains (L and A)
has to be set up each time to provide hybrids identical in age et time of
exposure.
The slightest error in hybridization not evident in LDSo teste
may be very significant with respect to chronic studies. Tf ac nge occurs
in either of the breeding parental strains, the hybrids will be different
and the analysis will become cumbersome, LAP, is homosygous, and it no more
imitates hybrids as a parental generation of a pure strain. Now we have some
unusual rdiation-induced tunara and do not have recipient LAP, mice for their
Therefore, we plead to try out a single strain to replace LA
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study.
futurs; much money and time (personnel) could be saved therett.
mice in the
There will
be no Mffionlty ef having such stock maintained by a commercial breeder
for studies at home laboratories.
In all probebility a Jackson “emorial
strain would be found acceptable. For selection of this strain or. Heston
at NeYeH. or Dr. <nell, Jackson Memorial Leboratary, Bar Harbor, could be
consulted.
Our RF mice should also be considered.
The are susceptible
not only to lymphoid but also to ayelold leukemias and ovarian, lung, and
other tumors,
They are very husky and free from Salmonella and other
infections. fr. Christenberry finds them very geod for cataract studies.
ea
eat
cu.
~~
Because of the urgency, a' copyte.being Soruarded to Dr. Cronkite to evaluate
the feasibility of this plan and soadvil se the planning committer.
‘We2
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